Grupo de Química de Ácidos Nucleicos del Instituto de Química Avanzada de Cataluña - GQNA-CSIC
Barcelona

Palabras clave

 

Síntesis, caracterización y funcionalización de nanopartículas mediante oligonucleótidos con grupos reactivos y su posible utilización en biosensores y mejora de la administración farmacológica en el ámbito biomédico, desarrollo de nanoconjugados de RNA para mejorar la actividad inhibitoria de los RNA de interferencia y nuevos compuestos intercalantes en ADN de doble cadena.

Consejo Superior de Investigaciones Científicas.
T. 934006145
Instituto de Química Avanzada de Cataluña C/ Jordi Girona, 18-26. Barcelona.
Barcelona. CP: 08034.

Responsable : Ramón Eritja Casadellá

Publicaciones

 

JCR 2011 

 

  • LUCAS R, GÓMEZ-PINTO I, AVIÑO A, REINA JJ, ERITJA R, GONZÁLEZ C ET AL. Highly Polar Carbohydrates Stack onto DNA Duplexes via CH/π Interactions. 2011 Jan 18. Journal of the American Chemical Society. DOI: 10.1021/ja108962j. Subject category: CHEMISTRY, MULTIDISCIPLINARY. 1st quartile, 1st decile. Impact factor: 9,023
  • JAUMOT J, ERITJA R, GARGALLO R. Chemical equilibria studies using multivariate analysis methods. 2011 Feb; 399(6):1983-97. Analytical and bioanalytical chemistry. DOI: 10.1007/s00216-010-4310-7. Subject category: BIOCHEMICAL RESEARCH METHODS. 2nd quartile, 3rd decile. Impact factor: 3,841
  • GRIJALVO S, OCAMPO SM, PERALES JC, ERITJA R. Synthesis of lipid-oligonucleotide conjugates for RNA interference studies. 2011 Feb;8(2):287-99. Chemistry & biodiversity.  DOI: 10.1002/cbdv.201000274. Subject category: CHEMISTRY, MULTIDISCIPLINARY. 2nd quartile, 4th decile. Impact factor: 1,586
  • TERRAZAS M, ERITJA R. Synthesis and properties of small interfering RNA duplexes carrying 5-ethyluridine residues. 2011 Aug; 15(3):677-86. Molecular diversity. DOI: 10.1007/s11030-010-9290-1. Subject category: CHEMISTRY, MEDICINAL. 1st quartile, 2nd decile. Impact factor: 3,721
  • AVIÑÓ A, OCAMPO SM, LUCAS R, REINA JJ, MORALES JC, PERALES JC ET AL. Synthesis and in vitro inhibition properties of siRNA conjugates carrying glucose and galactose with different presentations. 2011 Aug; 15(3):751-7. Molecular diversity. DOI: 10.1007/s11030-011-9305-6. Subject category: CHEMISTRY, MEDICINAL. 1st quartile, 2nd decile. Impact factor: 3,721
  • TERRAZAS M, OCAMPO SM, PERALES JC, MARQUEZ VE, ERITJA R. Effect of north bicycle [3.1.0]hexane 2'-deoxy-pseudosugars on RNA interference: a novel class of siRNA modification. 2011 May 2; 12(7):1056-65. Chembiochem: a European journal of chemical biology. DOI: 10.1002/cbic.201000791. Subject category: BIOCHEMISTRY & MOLECULAR BIOLOGY. 2nd quartile, 4th decile. Impact factor: 3,945
  • DICULESCU, V.C.; CHIORCEA-PAQUIM, A.M.; ERITJA, R.; OLIVEIRA-BRETT, A.M. Evaluation of the structure-activity relationship of thrombin binding aptamers by voltammetry and atomic force microscopy. J. electroanal.chem. 2011; 656(1-2):159-166. DOI: 10.1016/j.elechem.2010.11.037. Subject category: Chemistry, Analytical; Electrochemistry. 2nd quartile, 3rd decile. Impact factor: 2,732
  • FERREIRA R, ARTALI R, FARRERA-SINFREU J, ALBERICIO F, ROYO M, ERITJA R ET AL. Acridine and quindoline oligomers linked through a 4-aminoproline backbone prefer G-quadruplex structures. 2011 Aug; 1810(8):769-76. Biochimica et biophysica acta. DOI: 10.1016/j.bbagen.2011.04.013. Subject category: Biochemistry & Molecular Biology; Biophysics. 1st quartile, 2nd decile. Impact factor: 4,663. - Publication in collaboration with the group of Fernando Albericio Palomera.
  • TERRAZAS M, AVIÑÓ A, SIDDIQUI MA, MARQUEZ VE, ERITJA R. A direct, efficient method for the preparation of siRNAs containing ribo-like North bicyclo[3.1.0]hexane pseudosugars. 2011 Jun 3; 13(11):2888-91. Organic letters. DOI: 10.1021/ol200909j. Subject category: CHEMISTRY, ORGANIC. 1st quartile, 1st decile. Impact factor: 5,25
  • FERNÁNDEZ S, ERITJA R, AVIÑÓ A, JAUMOT J, GARGALLO R. Influence of pH, temperature and the cationic porphyrin TMPyP4 on the stability of the i-motif formed by the 5'-(C3TA2)4-3' sequence of the human telomere. 2011 Nov 1; 49(4):729-36. International journal of biological macromolecules. DOI: 10.1016/j.ijbiomac.2011.07.004. Subject category: BIOCHEMISTRY & MOLECULAR BIOLOGY. 3rd quartile, 6th decile. Impact factor: 2,502
  • GARIBOTTI AV, PÉREZ-RENTERO S, ERITJA R. Functionalization and self-assembly of DNA bidimensional arrays. 2011;12(9):5641-51. International journal of molecular sciences. DOI: 10.3390/ijms12095641. Subject category: CHEMISTRY, MULTIDISCIPLINARY. 2nd quartile, 3rd decile. Impact factor: 2,279
  • MANNING B, ERITJA R. Use of oligonucleotides carrying photolabile groups for the control of the deposition of nanoparticles in surfaces and nanoparticle association. 2011; 12(10):7238-49. International journal of molecular sciences.  DOI: 10.3390/ijms12107238. Subject category: CHEMISTRY, MULTIDISCIPLINARY. 2nd quartile, 3rd decile. Impact factor: 2,279

 

JCR  2010

 

  • Aviñó A, Mazzini S, Ferreira R, Eritja R. Synthesis and structural properties of oligonucleotides covalently linked to acridine and quindoline derivatives through a threoninol linker.Bioorg Med Chem. 2010 Nov 1;18(21):7348-56. DOI:  10.1016/j.bmc.2010.09.023 . Subject Category:  CHEMISTRY, ORGANIC . Cuartil  2 Decil  3 . FI :  2,822
  • Alvira M, Eritja R. Triplex-stabilizing properties of parallel clamps carrying LNA derivatives at the Hoogsteen strand.Chem Biodivers. 2010 Feb;7(2):376-82. DOI:  10.1002/cbdv.200900230 . Subject Category:  CHEMISTRY, MULTIDISCIPLINARY . Cuartil  2 Decil  4 . FI :  1,926
  • Grijalvo S, Terrazas M, Aviñó A, Eritja R. Stepwise synthesis of oligonucleotide-peptide conjugates containing guanidinium and lipophilic groups in their 3'-termini.Bioorg Med Chem Lett. 2010 Apr 1;20(7):2144-7. DOI:  10.1016/j.bmcl.2010.02.049 . Subject Category:  CHEMISTRY, ORGANIC . Cuartil  2 Decil  4 . FI :  2,65
  • Ugarte-Uribe B, Pérez-Rentero S, Lucas R, Aviñó A, Reina JJ, Alkorta I et al.. Synthesis, cell-surface binding, and cellular uptake of fluorescently labeled glucose-DNA conjugates with different carbohydrate presentation.Bioconjug Chem. 2010 Jul 21;21(7):1280-7. DOI:  10.1021/bc100079n . Subject Category:  BIOCHEMICAL RESEARCH METHODS . Cuartil  1 Decil  2 . FI :  4,35
  • Somoza A, Terrazas M, Eritja R. Modified siRNAs for the study of the PAZ domain.Chem Commun (Camb). 2010 Jun 28;46(24):4270-2. DOI:  10.1039/c003221b . Subject Category:  CHEMISTRY, MULTIDISCIPLINARY . Cuartil  1 Decil  2 . FI :  5,504
  • Pérez-Rentero S, Kielland N, Terrazas M, Lavilla R, Eritja R. Synthesis and properties of oligonucleotides carrying isoquinoline imidazo[1,2-a]azine fluorescent units.Bioconjug Chem. 2010 Sep 15;21(9):1622-8. DOI:  10.1021/bc1000966 . Subject Category:  BIOCHEMICAL RESEARCH METHODS . Cuartil  1 Decil  2 . FI :  4,35
  • Pérez-Rentero S, Garibotti AV, Eritja R. Solid-phase synthesis of oligodeoxynucleotides containing N4-[2-(t-butyldisulfanyl)ethyl]-5-methylcytosine moieties.Molecules. 2010 Aug 18;15(8):5692-707. DOI:  10.3390/molecules15085692 . Subject Category:  Chemistry, Organic . Cuartil  3 Decil  5 . FI :  1,738
  • Grijalvo S, Ocampo SM, Perales JC, Eritja R. Synthesis of oligonucleotides carrying amino lipid groups at the 3'-end for RNA interference studies.J Org Chem. 2010 Oct 15;75(20):6806-13. DOI:    . Subject Category:  CHEMISTRY, ORGANIC . Cuartil  1 Decil  2 . FI :  4,219
  • Manning B, Leigh SJ, Ramos R, Preece J, Eritja R . Fabrication of patterned surfaces by photolithographic exposure of DNA-hairpins carrying a novel photolabile groupJournal of Experimental Nanoscience. 2010;5(1):26-39. DOI:  10.1080/17458080903242314 . Subject Category:  Chemistry, Multidisciplinary . Cuartil  4 Decil  9 . FI :  0,614

 

JCR 2009 

 

  • AVIÑÓ A, PÉREZ-RENTERO S, GARIBOTTI AV, SIDDIQUI MA, MÁRQUEZ VE, ERITJA R, Synthesis and hybridization properties of modified oligodeoxynucleotides carrying non-natural bases. Chem. Biodivers. 2009; 6(2):117-126. DOI:   10.1002/cbdv200800239. Subject Category: Chemistry, Multidisciplinary, 2º cuartil, 4º decil. Impact Factor (2008): 1,659
  • RAMOS R, MANNING B, AVIÑÓ A, GARGALLO R, ERITJA R. Photocleavage of peptides and oligodeoxynucleotides carrying 2-nitrobenzyl groups. Helv. Chim. Acta. 2009; 92(4):613-622. DOI:   10.1002/hlca.200800361. Subject Category:  Chemistry, Multidisciplinary, 2º cuartil, 5º decil. Impact Factor (2008): 1,396
  • MARTÍNEZ MT, TSENGYC, ORMATEGUI N, GONZÁLEZ-DOMÍNGUEZ JM, LOINAZ I, ERITJA R, BOKOR J. Label-free DNA biosensors based on functionalized carbon nanotube field effect transistors. Nano Lett. 2009; 9(2):530-536. DOI: 10.1021/nl8025604. Subject Category:  Nanotechnology & Nanotech, 1er cuartil, 1er decil. Impact Factor (2008): 10,371   
  • JAUMOT J, ERITJA R, NAVEA S, GARGALLO R, Classification of nucleic acids structures by means of the chemometric analysis of circular dichroism spectra. Anal Chim. Acta. 2009; 642(1-2):117-12. DOI: 101016/j.aca.2008.12.052. Subject Category: Chemistry, Analytical, 1er cuartil, 2º decil. Impact Factor (2008): 3,146 
  • VAN BEMMEL DM, BRANK, AS, ERITJA R, MARQUEZ VE, CHRISTMAN JK, DNA(Cytosine-C5) methyltransferase inhibition by oligodeoxyribonucleotides containing 2-(1H)-pyrimidinone (zebularine aglycon) at the enzymatic target site. Biochem. Pharmacol. 2009; 78(6):633-641. DOI:    10.1016/j.bcp.2009.05.017. Subject Category: Pharmacology, 1er cuartil, 1er decil. Impact Factor (2008): 4,838  
  • TORT N, SALVADOR JP, ERITJA R, POCH M, MARTÍNEZ E, SAMITIER J, MARCO MP, Fluorescence site-encoded DNA addressable hapten-microarray for anabolic androgenic steroids. TrAC Trends in Analytical Chemistry. 2009; 28(6):718-728. DOI: 10.1016/j.trac.2009.04.003. Subject Category: Chemistry, Analytical, 1er cuartil, 1er decil. Impact Factor (2008): 5,485. Publicación en colaboración con los grupos de los IPs Pilar Marco y Josep Samitier
  • DEL TORO M, BUCEK P, AVIÑÓ A, JAUMOT J, GONZÁLEZ C, ERITJA R, GARGALLO R. Targeting the G–quadruplex forming region near the P1 promoter in the human BCL-2 gene with the cationic porphyrin TMPyP4 and with the complementary C-rich strand. Biochimie. 2009; 91(7):894-902. DOI: 10.1016/j.biochi.2009.04.012. Subject Category: Biochem & Molecular Biology, 2º cuartil, 5º decil . Impact Factor (2008): 3,071  
  • REIRIZ C, BREA RJ, ARRANZ R, CARRASCOSA JL, GARIBOTTI A, MANNING B, VALPUESTA JM, ERITJA R, CASTEDO L, GRANJA JR. Alfa,gamma-Peptide nanotube templating 1D parallel fullerene arrangements. J. Am. Chem. Soc. 2009; 131(32):11335-11337. DOI: 10.1021/ja904548q. Subject Category: Chemistry Multidisciplinary, 1er cuartil, 1er decil. Impact Factor (2008):  8,091
  • GARIBOTTI AV, SISQUELLA X, MARTÍNEZ E, ERITJA R. Assembly of two-dimensional DNA crystals carrying N4-[2-(tert-butyldisulfanyl)ethyl]-cytosine residues. Helv. Chim. Acta. 2009; 92(8):1466-1472. DOI:10.1002/hlca.200900186. Subject Category: Chemistry Multidisciplinary, 2º cuartil, 5º decil. Impact Factor (2008): 1,396. Publicación en colaboración con el grupo del IP Josep Samitier
  • FAUSTINO I, AVIÑO A, MARCHAN I, LUQUE FJ, ERITJA R, OROZCO M. Unique tautomeric and recognition properties of thioketothymines. J. Am. Chem. Soc. 2009; 131(35):12845-12853. DOI:  10.1021/ja904880y. Subject Category: Chemistry Multidisciplinary, 1er cuartil, 1er decil. Impact Factor (2008): 8,091  
  • BUCEK P, JAUMOT J, AVIÑO A, ERITJA R, GARGALLO R. pH-modulated Watson-Crick duplex- quadruplex equilibria of guanine-rich and cytosine-rich DNA sequences 140 bp upstream of the c-kit transcription initiation site. Chemistry Eur. J. 2009; 15(46):12663-12671. DOI: 10.1002/chem.200901631. Subject Category: Chemistry Multidisciplinary, 1er cuartil, 1er decil. Impact Factor (2008):   5,454 
  • SANEYOSHI H, MAZZINI S, AVIÑÓ A, PORTELLA G, GONZÁLEZ C, OROZCO, M, MARQUEZ V, ERITJA R, Conformationally rigid nucleoside probes help understand the role of sugar pucker and nucleobase orientation in the thrombin binding. Nucleic Acids Res. 2009; 37(17):5589-5601. DOI: 10.1093/nar/gkp598. Subject Category: Biochem & Molecular Biology, 1er cuartil, 2º decil. Impact Factor (2008): 6,878

 

JCR 2008

 

  • MAZZINI, S.; GARCÍA-MARTÍN, F.; ALVIRA, M.; AVIÑÓ, A.; MANNING, B.; ALBERICIO, F.; ERITJA, R. “Synthesis of oligonucleotide derivatives using ChemMatrix supports”. Chemistry and Biodiversity 5 (1): 209-218 (2008). Publicación EN COLABORACIÓN con el grupo PCB-UB, IP Fernando Albericio
  • DOWD, C.L.; SUTCH, B.T.; HAWORTH, I.S.; ERITJA, R.; MARQUEZ, V.E.; YANG, A.S. “Incorporation of Zebularine from its 2’-deoxyribonucleoside triphosphate derivative and activity as a template-coding nucleobase.” Nucleosides, Nucleotides & Nucleic Acids 27 (2): 131-145 (2008).
  • AVIÑÓ, A.; NAVARRO, I.; FARRERA-SINFREU, J.; ROYO, M.; AYMAMÍ, J.; DELGADO, A.; LLEBARIA, A.; ALBERICIO, F.; ERITJA, R. “Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones”. Bioorganic and Medicinal Chemistry Letters 18 (7): 2306-2310 (2008). Publicación EN COLABORACIÓN con el grupo PCB-UB, IP Fernando Albericio
  • FARRERA-SINFREU, J.; AVIÑÓ, A.; NAVARRO, I.;  AYMAMÍ, J.; BETETA, N.G.; VARÓN, S.; PÉREZ-TOMÁS, R.; CASTILLO-AVILA, W.; ERITJA, R.; ALBERICIO, F.; ROYO, M. “Design, synthesis and antiproliferative properties of oligomers with chromophore units linked by amide backbones”. Bioorganic and Medicinal Chemistry Letters, 18 (7): 2440-2444 (2008)Publicación EN COLABORACIÓN con el grupo PCB-UB, IP Fernando Albericio
  • GROS, J.; AVIÑÓ, A.; LÓPEZ DE LA OSA, J.; GONZÁLEZ, C.; LACROIX, L.; PÉREZ, A.; OROZCO, M.; ERITJA, R.; MERGNY, J.L. “8-amino guanine accerelates tetramolecular G-quadruplex formation”. Chemical Communication 25: 2926-2928 (2008).
  • DEL TORO, M.; GARGALLO, R.; ERITJA, R.; JAUMOT, J. “Study of the interaction between the G-quadruplex-forming thrombin-binding aptamer and the porphyrin 5,10,15,20-tetrakis-(N-methyl-4-pyridyl)-21,23H-porphyrin tetratosylate”. Analytical Biochemistry 379 (1): 8-15 (2008).
  • MORALES, J.C.; REINA, J.J.; DÍAZ, I.; AVIÑÓ, A.; NIETO, P.M.; ERITJA, R. “Experimental measurement of carbohydrate aromatic stacking in water using a dangling-ended DNA model system”. Chemistry-A European Journal 14 (26): 7828-7835 (2008).

 

JCR 2007

 

  • Bermejo, J.F.; Ortega, P.; Chonco, L.; Eritja, R.; Samaniego, R.; Müllner, M.; de Jesús, E.; de la Mata, F.J.; Flores, J.C.; Gómez, R.; Muñóz-Fernández, A., “Water-soluble carbosilane dendrimers: Synthesis, biocompatibility and complexation with oligonucleotides; evaluation for medical applications”. Chemistry, Eur. J., 13, 485-487.  (2007) (JCR, 1er cuartil) Compartida con el grupo de Rafael Gómez y Maria Ángeles Muñoz-Fernández.
  • Vives, M.; Tauler, R.; Eritja, R.; Gargallo, R.; “Spectroscopic study of the interaction of actinomycin D with oligonucleotides carrying the central base sequences XGCY- and XGGCCY- using multivariate methods”. Anal. Bioanal. Chem., 387, 311-320. (2007) (JCR, 1er cuartil)
  • Eritja, R.; “Solid-phase synthesis of modified oligonucleotides”. Int. J. Pept. Res. Ther., 13, 53-68. (2007)
  • Portela, C.; Albericio, F.; Eritja, R.; Castedo, L.; Mascareñas, J.L, “Ds-Oligonucleotide-peptide conjugates featuring peptides from the leucine zipper region of fos as switchable receptors for the oncoprotein Jun”. ChemBioChem. 8, 1110-1114. (2007) (JCR: 1er cuartil) Compartida con el grupo de Fernando Albericio.
  • Shcharbin, D.; Pedziwiatz, E.; Chonco, L.; Bermejo-Martin, J.; Ortega, P.; de la Mata, F.J.; R. Eritja, R. Gómez, B. Klajnert, M. Bryszewska, M.A. Muñoz-Fernández (2007) “Analysis of interaction between dendriplexes and bovine serum albumin”. Biomacromolecules, 8, 2059-2062. (2007) (JCR, 1er cuartil) Compartida con el grupo de Rafael Gómez y Mª Ángeles Muñoz-Fernández.
  • Chonco, L.; Bermejo-Martín, J.F.; Ortega, P.; Shcharbin, D.; Pedziwiatr, E.; Klajnert, B.; de la Mata, F.J.; R. Eritja, R. Gómez, M. Bryszewska, M.A. Muñoz-Fernández., “Water-soluble carbosilane dendrimers protect phosphorothioate oligonucleotides from binding to serum proteins”. Org. Biomol. Chem., 5, 1886-1893. (2007).  Publicación en colaboración con el grupo de Rafael Gómez y Mª Ángeles Muñoz-Fernández.
  • Alvira, M.; Eritja, R., “Synthesis of oligonucleotides carrying 5’-5’ linkages using copper-catalyzed cycloaddition reactions”. Chem. Biodivers., 4 2798-2809 (2007) (JCR)
  • Khan, N.; Aviñó, A.; Tauler, R.; González, C.; Eritja, R.; Gargallo, R.; “Solution equilibria of the i-motif-forming region upstream of the B-cell lymphoma-2 P1 promoter.”, Biochimie, 89 1562-1572 (2007) (JCR)