1987-1988- University of Marburg, Germany.Postdoctoral Fellow, Prof. Miguel Beato

1988-1991- European Molecular Biology Laboratories (EMBL). Heidelberg, Germany, Postdoctoral Fellow, Prof. Denis Duboule

1988-1991-University College, London. London, England, Visiting Fellow, Prof. Lewis Wolpert

1988-1991-Oxford University.Oxford, England, Visiting Fellow, Prof. Claudio Stern

1992-1993 -University of California, Los Angeles, USA. Postdoctoral Fellow,Prof. Eddy De Robertis

1993-1998 -The Salk Institute, San Diego, USA.Assistant Professor

1993-University of California, San Diego, USA. Adjunct Professor

1998- 2000The Salk Institute, San Diego, USA.Associate Professor

2000-The Salk Institute, San Diego, USA.Professor

2004- Center of Regenerative Medicine, Barcelona, Director

1980-1985,University of Valencia, Spain. M. Sc. (Honors). Pharmacology

1985-1987, University of Bologna, Italy and University of Valencia, Spain,

Ph.D. Graduate Student. Biochemistry and Pharmacology. Prof. José Cabo

Last 11 years

Menendez S, Camus S, Herreria A, Paramonov I, Batlle Morera L, Collado M, Pekarik V, Maceda I, Edel M, Consiglio A, Sanchez A, Li H, Serrano M, Izpisúa Belmonte JC. (2011) Increased dosage of tumor suppressors limits the tumorigenicity of iPS cells without affecting their pluripotency. Aging Cell, Oct 10. [Epub ahead of print]

Montserrat N, de Oñate L, Garreta E, González F, Adamo A, Eguizábal C, Häfner S, Vassena R, Izpisúa Belmonte JC. (2011) Generation of feeder free pig induced pluripotent stem cells without Pou5f1. Cell Transplant, Sep 23. [Epub ahead of print]

Yasuhiko Kawakami, Merce Marti, Hiroko Kawakami, Junji Itou, Thu Quach, Austin Johnson, Setsuko Sahara, Dennis D. M. O’Leary, Yasushi Nakagawa, Mark Lewandoski, Samuel Pfaff, Sylvia M. Evans and Juan Carlos Izpisúa Belmonte. (2011) Islet1-mediated activation of the beta-catenin pathway is necessary for hindlimb initiation in mice. Development 138: 4465-4473.

Adamo A, Barrero MJ, Izpisúa Belmonte JC. (2011) LSD1 and pluripotency: A new player in the network. Cell Cycle Oct 1, 10(19). [Epub ahead of print]

Sanchez-Danes A, Consiglio A, Richaud Y, Rodriguez-Piza I, Dehay B, Edel M, Bove J, Memo M, Vila M, Raya A, Izpisua Belmonte JC. (2011) Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and iPS cells. Human Gene Therapy Aug 30. [Epub ahead of print]

Terme JM, Sese B, Millan-Arino L, Mayor R, Izpisúa Belmonte JC, Barrero MJ, Jordan A. Histone H1 variants are differentially expressed and incorporated into chromatin during differentiation and reprogramming to pluripotency. J Biol Chem. 2011 Aug 18. [Epub ahead of print]

Panopoulos AD, Izpisúa Belmonte JC. (2011) Anaerobicizing into pluripotency. Cell Metab 14(2): 143-4.

Danielle A. Murphy, Begoña Diaz, Paul A. Bromann, Jeff H. Tsai, Yasuhiko Kawakami, Jochen Maurer, Rodney A. Stewart, Izpisúa Belmonte JC, Sara A. Courtneidge. (2011) A Src-Tks5 Pathway Is Required for Neural Crest Cell Migration during Embryonic Development. PLoS ONE 6(7): e22499.

Rita Vassena, Stéphanie Boué, Eva González-Roca, Begoña Aran, Herbert Auer, Anna Veiga and Izpisúa Belmonte JC (2011) Waves of early transcriptional activation and pluripotency program initiation during human preimplantation development. Development 138(17): 3699-709.

Eguizabal C, Montserrat N, Vassena R, Barragan M, Garreta E, Garcia-Quevedo L, Vidal F, Giorgetti A, Veiga A, Izpisúa Belmonte JC. (2011) Complete Meiosis from Human Induced Pluripotent Stem Cells. Stem Cells 29(8):1186-95.

Fütterer A, Raya A, Llorente M, Izpisúa-Belmonte JC, de la Pompa JL, Klatt P, Martínez-A C. (2011) Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development. Cell Death Differ. Jun 10. [Epub ahead of print]

Liu GH, Suzuki K, Qu J, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet E, Kim J, Soligalla RD, Dubova I, Goebl A, Plongthongkum N, Fung HL, Zhang K, Loring JF, Laurent LC, Izpisúa Belmonte JC. (2011) Targeted Gene Correction of Laminopathy-Associated LMNA Mutations in Patient-Specific iPSCs. Cell Stem Cell 8(6): 688-94.

Adamo A, Sesé B, Boue S, Castaño J, Paramonov I, Barrero MJ, Izpisúa Belmonte JC. (2011) LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells. Nat Cell Biol 13(6): 652-60. 

Athanasia D. Panopoulos, Sergio Ruiz, Fei Yi, Aída Herrerías, Erika M. Batchelder, Izpisúa Belmonte JC. (2011) Rapid and Highly Efficient Generation of Induced Pluripotent Stem Cells from Human Umbilical Vein Endothelial Cells. PLoS ONE May, 6(5): e19743.

Giorgetti, A., Fazzina, R., Li, M. and Izpisúa Belmonte, JC. (2011) Human cord blood reprogrammed into embryonic-like stem cells. ISBT Science Series 6: 107-111.

Woods NB, Parker AS, Moraghebi R, Lutz MK, Firth AL, Brennand KJ, Berggren WT, Raya A, Izpisúa Belmonte JC, Gage FH, Verma IM. (2011) Brief report: Efficient Generation of Hematopoietic Precursors and Progenitors From Human Pluripotent Stem Cell Lines. Stem Cells 29(7): 1158-64.

Robles V, Martí M, Izpisúa Belmonte JC. Study of Pluripotency Markers in Zebrafish Embryos and Transient Embryonic Stem Cell Cultures. Zebrafish 8(2): 57-63.

Barrero MJ, Izpisúa Belmonte JC. (2011) iPS cells forgive but do not forget. Nat Cell Biol, 13(5): 523-5.

Menchón C, Edel MJ, Izpisúa Belmonte JC. (2011) The cell cycle inhibitor p27Kip1 controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle, Brachyury and Twist. Cell Cycle 10(9): 1435-47.

Edel MJ, Menchon C, Andres Vaquero JM, Izpisúa Belmonte JC. (2011) A protocol to assess cell cycle and apoptosis in human and mouse pluripotent cells. Cell Commun Signal. Apr 11 9(1): 8.

Panopoulos AD, Ruiz S, Izpisúa Belmonte JC. (2011) iPSCs: Induced Back to Controversy. Cell Stem Cell, Apr 8 8(4): 347-8.

Tiscornia G, Monserrat N, Izpisúa Belmonte JC. (2011) Modelling Long QT Syndrome With iPS Cells: Be Still, My Beating Heart ... Circ Res, Mar 18, 108(6): 648-9.

Sancho-Martinez I, Li M, Izpisúa Belmonte JC. (2011) Disease Correction the iPSC Way: Advances in iPSC-Based Therapy. Clin Pharmacol Ther 89(5): 746-9.

Kim S, Izpisúa Belmonte JC. (2011) Pluripotency of male germline stem cells. Mol Cells 32(2): 113-121.

Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisúa Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. (2011) Somatic coding mutations in human induced pluripotent stem cells. Nature 471 (7336): 63-7.

Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, Iii JY, Izpisúa Belmonte JC. (2011) Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature Apr 14, 472(7342): 221-5.

González F, Boué S, Izpisúa Belmonte JC. (2011) Methods for making induced pluripotent stem cells: reprogramming à la carte. Nat Rev Genet 12(4): 231-42.

Barrero MJ, Izpisúa Belmonte JC. (2011) Regenerating the epigenome. EMBO Rep. 12(3): 208-15.

Montserrat N, Garreta Bahima E, Gonzalez F, Gutierrez J, Eguizabal C, Ramos Perez V, Borros S, Izpisua Belmonte JC. (2011) Simple generation of human induced Pluripotent stem cells using Poly({beta}-Amino Esters) as non-viral gene delivery system. J Biol Chem 286(14): 12417-28.

Chris Jopling, Stephanie Boue & Izpisúa Belmonte JC. (2011) Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration. Nature Reviews Molecular Cell Biology 12, 79-89.

Li M, Sancho-Martinez I, Izpisúa Belmonte JC. (2011) Cell fate conversion by mRNA. Stem Cell Res Ther. 2(1): 5.

Isao Oishi, Sungtae Kim, Kyoko Yoshi, Concepcion Rodriguez Esteban and Izpisua Belmonte JC. (2011) Cre-LoxP-regulated expression of monoclonal antibodies driven by an ovalbumin promoter in primary oviduct cells. BMC Biotechnology, Jan 14 11(1): 5.

Montserrat N, Bahima EG, Batlle L, Häfner S, Rodrigues AM, González F, Belmonte JC. (2011) Generation of Pig iPS Cells: A Model for Cell Therapy. J Cardiovasc Transl Res 4(2): 121-30.

Louise C. Laurent, Igor Ulitsky, Ileana Slavin, Ha Tran, Andrew Schork, Robert Morey, Candace Lynch, Julie V. Harness, Sunray Lee, Maria J. Barrero, Sherman Ku, Marina Martynova, Ruslan Semechkin, Vasiliy Galat, Joel Gottesfeld, Izpisúa Belmonte JC, Chuck Murry, Hans S. Keirstead, Hyun-Sook Park, Uli Schmidt, Andrew L. Laslett, Franz-Josef Muller, Caroline M. Nievergelt, Ron Shamir, and Jeanne F. Loring. (2011) Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and iPSCs during Reprogramming and Time in Culture. Cell Stem Cell 8, 106–118.

Ruiz S, Panopoulos AD, Herrerías A, Bissig KD, Lutz M, Berggren WT, Verma IM, Izpisúa Belmonte JC. (2011) A High Proliferation Rate Is Required for Cell Reprogramming and Maintenance of Human Embryonic Stem Cell Identity. Curr Biol, Jan 1121(1): 45-52.

Tiscornia G and Izpisúa Belmonte JC. (2010) MicroRNAs in embryonic stem cell function and fate. Genes Dev Dec 15, 24(24): 2732-41.

Ruiz S, Brennand K, Panopoulos AD, Herrerias A, Gage FH, Izpisúa Belmonte JC. (2010) High-Efficient Generation of Induced Pluripotent Stem Cells from Human Astrocytes. PLoS ONE Dic; 5(12): e15526.

Barrero MJ, Boué S, Izpisúa Belmonte JC. (2010) Epigenetic Mechanisms that Regulate Cell Identity. Cell Stem Cell, Nov 5, 7(5): 565-70.

Menendez S, Camus S, Izpisúa Belmonte JC. (2010) p53: Guardian of reprogramming. Cell Cycle, Oct 1 9(19):3887-91. 

Pere Santamaria, Ignacio Rodríguez-Pizá, Xavier Clemente-Casares, Jun Yamanouchi, Lola Mulero-Perez, Trond Aasen, Angel Raya, Izpisúa Belmonte JC. (2010) Turning Human Epidermis Into Pancreatic Endoderm. Rev Diabet Stud, 7(2): 151-160.

Boué S, Paramonov I, Barrero MJ, Izpisúa Belmonte JC. (2010) Analysis of Human and Mouse Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells. What Is in the Plate? PLoS ONE Sep 17; 5(9). pii: e12664.

Montserrat N, Jopling C, Izpisúa Belmonte JC. (2010) Understanding the molecular basis for cardiomyocyte cell cycle regulation: new insights in cardiac regeneration after injury? Expert Rev Cardiovasc Ther, Aug 8(8): 1043-5.

Masip M, Veiga A, Izpisúa JC, Simón C. (2010) Reprogramming with defined factors: from induced pluripotency to induced transdifferentiation. Mol Hum Reprod 16: 856-868.

Bayes-Genis, A., Soler-Botija, C., Farre, J., Sepulveda, P., Raya, A., Roura, S., Prat-Vidal, C., Galvez, C., Anastasio Montero, J., Buscher, D. and Izpisua Belmonte, JC. (2010) Identification of a novel progenitor cell population from adult human cardiac adipose tissue with potential for cardiac repair. Journal of Molecular and Cellular Cardiology 49: 771-780.

Isaacs MJ, Kawakami Y, Allendorph GP, Yoon B, Izpisúa Belmonte JC, and Choe S. (2010) Bone morphogenetic protein-2 and -6 heterodimer illustrates the nature of ligand-receptor assembly. Molecular Endocrinology, Jul 24(7): 1469-77.

Edel, M. and Izpisúa Belmonte, JC. (2010) The cell cycle and pluripotency: Is there a direct link? Cell Cycle 9: 2694-2695.

Valera E, Isaacs MJ, Kawakami Y, Izpisúa Belmonte JC, Choe S. (2010) BMP-2/6 heterodimer is more effective than BMP-2 or BMP-6 homodimers as inductor of differentiation of human embryonic stem cells. PLoS One Jun 17; 5(6): e11167.

Sleep E, Boué S, Jopling C, Raya M, Raya A, Izpisúa Belmonte, JC. (2010) Transcriptomics approach to investigate zebrafish heart regeneration. J Cardiovasc Med (Hagerstown) May, 11(5): 369-80.

Giorgetti A, Montserrat N, Rodriguez-Piza I, Azqueta C, Veiga A, Izpisúa Belmonte, JC. (2010) Generation of induced pluripotent stem cells from human cord blood cells with only two factors: Oct4 and Sox2. Nature Protocols 5(4): 811-20.

Raya, A, Rodriguez-Piza, I, Navarro, S, Richaud, Y, Guenechea, G, Sanchez-Danes, A, Consiglio, A, Bueren, J and Izpisúa Belmonte, JC. (2010) A protocol describing the genetic correction of somatic human cells and subsequent generation of iPS cells. Nature Protocols 5(4): 647-60.

Chris Jopling, Eduard Sleep, Marina Raya, Mercè Martí, Angel Raya & Izpisúa Belmonte JC. (2010) Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature Mar 25; 464 (7288): 606-9.

Michael J. Edel, Cristina Menchón, Sergio Menéndez, Antonella Consiglio, Angel Raya, and Izpisúa Belmonte JC. (2010) Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1. Genes Dev 24: 561-573.

Sugii S, Kida Y, Kawamura T, Suzuki J, Vassena R, Yin YQ, Lutz MK, Berggren WT, Izpisúa Belmonte JC, Evans RM. (2010) Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells. Proc Natl Acad Sci U S A. Feb 23, 107(8): 3558-63.

Christen, B, Robles, V, Raya, M, Paramonov, I and Izpisúa Belmonte JC. (2010) Regeneration and reprogramming compared. BMC Biol. Jan 20; 8:5.

Shigeki Sugiia, Yasuyuki Kida, Teruhisa Kawamura, Jotaro Suzuki, Rita Vassena, Yun-Qiang Yin, Margaret K. Lutz, W. Travis Berggren, Izpisúa Belmonte JC, and Ronald M. Evans. (2010) Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells. PNAS Feb 23; 107(8): 3558-63.

Aasen, T. and Izpisúa Belmonte JC. (2010) Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells. Nature Protocols 5(2): 371-82.

Tramullas, M., Diaz, A., San-Emeterio, E.P., Morchon, N., Lantero, A., Merino, D., Buscher, D., Merino, R., Hurle, J.M., Izpisúa Belmonte JC and Hurle, M. (2010) BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) reveals the involvement of the transforming growth factor-beta family in pain modulation. Journal of Neuroscience Jan 27; 30(4): 1502-11.

Mizrak, S.C., Chikhovskaya, J.V., Sadri-Ardekani, H., van Daalen, S., Korver, C.M., Hovingh, S.E., Roepers-Gajadien, H.L., Raya, A., Fluiter, K., de Reijke, Th.M., de la Rosette, J.J.M.C.H., Izpisúa Belmonte JC, van der Veen, F., de Rooij, D.G. and van Pelt, A.M.M. (2010) Embryonic Stem Cell-like Cells Derived from Adult Human Testis. Human Reproduction, Jan 25(1): 158-67.

Rodriguez-Piza, I., Richaud-Patin, Y., Vassena, R., Gonzalez, F., Barrero, M.J., Veiga, A., Raya, A. and Izpisúa Belmonte JC. (2010) Reprogramming of human fibroblasts to induced pluripotent stem cells under xeno-free conditions. Stem Cells, Jan 28(1): 36-44.

Ibanes, M. and Izpisúa Belmonte JC. (2009) Left-right asymmetry determination. Wiley Interdisciplinary Reviews: Systems Biology and Medicine. Sept/Oct: 210-219.

Aran B, Rodriguez-Pizà I, Raya A, Consiglio A, Muñoz Y, Barri PN, Izpisúa Belmonte JC, Veiga A. (2010) Derivation of human embryonic stem cells at the Center of Regenerative Medicine in Barcelona. In Vitro Cellular & Developmental Biology - Animal, Apr 46(3-4): 356-66.

B.Aran, A.Veiga, Izpisúa Belmonte JC. (2009) Células madre pluripotentes Revista Arbor. In press.

Stewart, S., Tsun, Z.Y. and Izpisúa Belmonte JC. (2009) A histone demethylase is necessary for regeneration in zebrafish. PNAS  106(47):  19889-19894.

Giorgetti, A., Montserrat, N., Aasen, T., Rodriguez-Piza, I., Vassena, R., Gonzalez, F., Boue, S., Barrero, M.J., Aran Corbella, B., Raya, A., Torrebadella, M., Veiga, A. and Izpisúa Belmonte JC. (2009) Generation of induced pluripotent stem cells from cord blood using OCT4 and SOX2. Cell Stem Cell. 5:353-357.

Izpisúa Belmonte JC, Ellis, J., Hochedlinger, K. and Yamanaka, S. (2009) Induced pluripotent stem cells and reprogramming: seeing the science through the hype. Nature Reviews Genetics 10: 878-883.

Kawamura, T., Suzuki, J., Wang, Y.V., Menendez, S., Batlle, L., Wahl, G. and Izpisúa Belmonte JC. (2009) Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 460: 1140-1144.

Kan, N., Junghans, D. and Izpisúa Belmonte JC. (2009) Compensatory growth mechanisms regulated by BMP and FGF signaling pathways mediate liver regeneration in zebrafish after partial hepatectomy. FASEB 23: 3516-3525.

Raya, A., Rodriguez-Piza, I., Guenechea, G., Vassena, R., Navarro, S., Barrero, M.J., Consiglio, A., Rio, P., Sleep, E., Tiscornia, G., Garreta, E., Aasen, T., Veiga, A., Verma, I., Bueren, J. and Izpisúa Belmonte JC. (2009) Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460 (7251): 53-9.

Kelber, J.A., Panopoulos, A.D., Shani, G., Booker, E.C., Izpisúa Belmonte JC, Vale, W.W. and Gray, P.C. (2009) Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPk/PI3K and Smad2/3 pathways. Oncogene 28: 2324-2336.

Gonzalez, F., Barragan Monasterio, M., Tiscornia, G., Montserrat Pulido, N., Vassena, R., Batlle Morera, L., Rodriguez Piza, I. and Izpsiua Belmonte JC. (2009) Generation of mouse induced pluripotent stem cells by transient expression of a single non-viral polycistronic vector. PNAS 106(22): 8918-8922.

Beck, C., Izpisúa Belmonte JC and Christen, B. (2009) Beyond Early Development: Xenopus as an emerging model for the study of regenerative mechanisms. Developmental Dynamics. 238(6): 1226-48.

Jopling, C. and Izpisúa Belmonte JC. (2009) Cilia-Where Two Wnts Collide. Zebrafish 6(1): 15-19.

Fink, M., Chu, A., Ruiz-Lozano, P., Callol, C., Izpisúa Belmonte JC, Giles, W., Bodmer, R. and Ocorr, K. (2009) A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts. Biotechniques 46: 101-113.

Rojas-Muñoz, A., Rajadhyksha, S., Gilmour, D., van Bebber, F., Rodríguez-Esteban, C., Nüsslein-Volhard, C., & Izpisúa Belmonte JC. (2009) ErbB2 and ErbB3 regulate amputation-induced proliferation and migation during vertebrate regeneration. Developmental Biology 327: 177-190.

Raya, A., Rodriguez-Piza, I., Aran, B., Consiglio, A., Barri, P., Veiga, A., and Izpisúa Belmonte JC. (2009) Generation of cardiomyocytes from new human embryonic stem cell lines derived from poor-quality blastocysts. 73rd Cold Spring Harbor Laboratory Symposium. 73:1-9.

Raya, A and Izpisúa Belmonte JC. (2009) Stem Cell Research in Spain: If Only They Were Windmills. Cell Stem Cell 4(6): 483-486.

Kawakami, Y., Uchiyama, Y., Rodriguez Esteban, C., Toshiaki, I., Kawakami, H., Marti, M., Kmita, M., Monaghan-Nicols, P., Nishinakamura, R. and Izpisúa Belmonte JC. (2008) Sall genes regulate region specific morphogenesis in the limb by modulating Hox activities. Development 136: 585-594.

Stubbs, J., Oishi, I., Izpisúa Belmonte JC and Kintner, C. (2008) The Forkhead protein, FoxJ1, specified node-like cilia in Xenopus and Zebrafish embryos. Nature Genetics. 40:1454-1460.

Ibanes, M. and Izpisúa Belmonte JC. (2008) Left-right asymmetry determination. Wiley Interdisciplinary Reviews: Systems Biology and Medicine. In Press.

Aasen, T., Raya, A., Barrero, M.J., Garreta, E., Consiglio, A., Gonzalez, F., Vassena, R., Bilic, J., Pekarik, V., Tiscornia, G., Edel, M., Boue, S. and Izpisúa Belmonte JC. (2008) Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nature Biotechnology. 26:1276-1284.

Raya, A. and Izpisúa Belmonte JC. (2008) Insights into the establishment of left-right asymmetries in vertebrates. BDRC: Embryo Today. 84(2):81-94.

Ibanes, M and Izpisúa Belmonte JC. (2008) Theoretical and experimental approaches to understand morphogen gradients. Nature Molecular Systems Biology. 4:176.

Pekarik, V. and Izpisúa Belmonte JC. (2008) NFIX-One Gene, Two Knockouts, Multiple Effects. Journal of Biology. 7:29.

Kurpios, N.A., Ibanes, M., Davis, N.M., Lui, W., Katz, T., Martin, J.F., Izpisúa Belmonte JC and Tabin, C.J. (2008) Directional gut looping is mediated by changes in the extracellular matrix and in cell:cell adhesion. PNAS. 105:8499-8506.

Moreno, T.A., Jappelli, R., Brenner, S., Izpisúa Belmonte JC, and Kintner, C. (2008) Retinoic Acid Regulation of the Mesp-Ripply Feedback Loop During Vertebrate Segmental Patterning. Developmental Biology. 315:317-330.

Suzuki, A., Sayaka, S., Buscher, D., Izpisúa Belmonte JC, and Taniguchi, H. (2008) Tbx3 controls hepatic stem cell fate in liver development by suppressing p19ARF expression. Development. 135:1589-1595

Garcia-Gonzalo, F.R. and Izpisúa Belmonte JC. (2008) Albumin-associated Lipids Regulate Human Embryonic Stem Cell Self-Renewal. PLoS ONE, Jan 2; 3(1): e1384.

Rodríguez-León J, Rodríguez Esteban C, Martí M, Santiago-Josefat B, Dubova I, Rubiralta X, Izpisúa Belmonte JC. (2008) Pitx2 regulates gonad morphogenesis. PNAS 105(32):11242-7.

Barrero, M.J. and Izpisua Belmonte J.C. (2008) Epigenetic Mechanisms Controlling Mesodermal Specification. StemBook, doi/10.3824/stembook.1.9.1 StemBook, ed (Harvard)

Allendorph, G.P., Isaacs, M.J., Kawakami, Y., Izpisúa Belmonte JC, Choe, S. (2007) BMP-3 and BMP-6 Structures Illuminate the Nature of Binding Specificity with Receptors. Biochemistry. 46:12238-12247.

Stewart, S., Rojas-Munoz, A., and Izpisúa Belmonte JC. (2007) Bioelectricity and epimorphic regeneration. Bioessays. 29(11):1133-1137.

Sahara, S., Kawakami, Y., Izpisúa Belmonte JC, O'Leary, D.D.M. (2007) Dual roles of Sp8 on cortical area patterning for anterior or posterior identities. Neuronal Development, 2:10.

Ribeiro, R., Kawakami, Y., Buscher, D., Raya, A., Rodriguez-Leon, J., Morita, M., Rodriguez Esteban, C., Izpisúa Belmonte JC. (2007) Tbx2 and Tbx3 regulate the dynamics of cell proliferation during heart regionalization and looping. PLoS One, Apr 25; 2(4): e398.

Rojas-Munoz, A., Bernad Miana, A., and Izpisúa Belmonte JC. (2007) El pez cebra:la navaja suiza de la biologia. Investigacion y Ciencia. 366:62-69.

Zuzarte-Luis, V., Montero, J.A., Kawakami, Y., Izpisúa Belmonte JC, and Hurle, J. (2007) Lysosomal cathepsins in embryonic programmed cell death. Developmental Biology. 301:205-217.

Matsui, T., Raya, A., Callol, C., Kawakami, Y., Oishi, I., Rodriguez-Esteban, C., and Izpisúa Belmonte JC. (2007) Miles apart-mediated regulation of cell-Fibronectin interaction is required for proper myocardial migration in zebrafish. Nature Clinical Practice Cardiovascular Medicine. 4:S77-S82.

Kawakami, Y., Rodriguez Esteban, C., Raya, M., Kawakami, H., Marti, M., Dubova, I., and Izpisúa Belmonte JC. (2006) Wnt/ß-catenin signaling regulates vertebrate limb regeneration. Genes and Development. 20:3232-3237.

Kawakami, Y., Rodriguez-Leon, J., Izpisúa Belmonte JC. (2006) The role of TGFßs and Sox9 during limb chondrogenesis. Current Opinion in Cell Biology. 18:723-729.

Oishi, I., Kawakami, Y., Raya, A., Callol-Massot, C., Izpisúa Belmonte JC. (2006) Regulation of primary cilia formation and left-right patterning in zebrafish by duboraya, a novel mediator of non-canonical Wnt signaling. Nature Genetics. 38:1316-1322.

Ibanes, M., Rasskin-Gutman, D., Kawakami, Y., and Izpisúa Belmonte JC. (2006) Cell lineage transport: a mechanism for molecular gradient formation. Nature Molecular Systems Biology. 2:57.

Suzuki, A.,Raya, A., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F.H.,Rodriguez-Esteban, C., and Izpisúa Belmonte JC. (2006) Nanog binds to Smad1and blocks BMP-induced differentiation of embryonic stem cells. PNAS 103: 10294-10299.

Soler-Botija,C., Cervera, R.P., Oishi, I., Raya, R.M., Dubova, I., Rodriguez-Esteban, C., Izpisúa Belmonte JC. (2006) Understanding embryonic heart development as atool for cardiac cell based therapy. Annals of Pediatrics 64: 15-22.

Weninger,W.J., Geyer, S.H., Mohun, T.J., Rasskin-Gutman, D., Matsui, T., Ribeiro, I.,Costa, L., Izpisúa Belmonte JC, Muller, G. B. (2006) High resolutionepiscopic microscopy: a rapid technique for high detailed 3D analysis of geneactivity in the context of tissue architecture and morphology. Anatomy and Embryology 211: 213-221.

Raya, A., Izpisúa Belmonte JC. (2006) Vertebrate left-right asymmetry: a convergence ofdivergences. Nature Reviews Genetics 7: 283-293.

Suzuki, A.,Raya, A., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F.H.,Rodriguez-Esteban, C., Izpisúa Belmonte JC. (2006) Maintenance of embryonicstem cell pluripotency by Nanog-mediated reversal of mesoderm specification. Nature Clinical Practice Cardiovascular Medicine 3: S114-S122.

Merki, E., Zamora, M., Raya, A., Kawakami, Y., Zhang, X., Burch, J., Kubalak, S., Kaliman, P., Izpisúa Belmonte JC, Chien, K., Ruiz-Lozano, P. (2005) Epicardial RXRa is required for myocardial growth and coronary artery formation. PNAS 102: 18455-18460.

Leusch, H., Chanda,S.K., Raya, R.M., DeJesus, P.D., Orth, A.P. Walker, J.R., Izpisúa Belmonte JC, Schultz, P. (2006) A functional genomics approach to the mode of actionof apratoxin A. Nature Chemical Biology 2: 158-167.

Okada, Y.,Takeda, S., Tanaka Y., Izpisúa Belmonte JC, and Hirokawa, N. (2005) Mechanism of Ciliated Organ Flow: a Conserved Symmetry Breaking Event inLeft-Right Axis Determination. Cell 121: 633-644.

Kawakami,Y., Raya, A., Raya, R.M., Rodriguez-Esteban, C., Izpisúa Belmonte JC. (2005). Retinoic acid signaling links left-right asymmetric patterning andbilaterally symmetric somitogenesis in the zebrafish embryo. Nature May 12; 435(7039): 165-71.

Correa, R.,Matsui, T., Tergaonkar, V., Rodriguez-Esteban, C., Izpisúa Belmonte JC, Verma, I. (2005) Zebrafish IkB kinase 1 (Ikk1) negatively regulates NF-kBactivity. Current Biology 15: 1291-1295.

Da FontouraCosta, L., Travencolo, B.A.N., Azeredo, A., Beletti, M.E., Rasskin-Gutman, D.,Sternik, G., Izpisúa Belmonte JC, Ibanes, M., and Muller, G. (2005) A NovelFiel Approach to 3D Gne Expression Pattern Characterization. Applied PhysicsLetters 86: 143901-143903.

Francisco-Morcillo,J., Sanchez-Calderon, H., Kawakami, Y., Izpisúa Belmonte JC, Hidalgo-Sanchez, M., Martin-Partido, G. (2005) Expression of Fgf19 in thedeveloping eye. Developmental Brain Research 156: 104-109.

Kawakami,Y., Tsuda, M., Takahashi, S., Taniguchi, N., Rodriguez-Esteban, C., Zemmyo, M.,Furumatsu, T., Lotz, M., Izpisúa Belmonte JC and Asahara, H. (2005). Transcriptional co-activator PGC-1 regulates chondrogenesis via associationwith Sox 9. PNAS 102: 2414-2419.

Matsui, T.,Raya, A., Kawakami, Y., Callol, C., Capdevila, J., Rodriguez-Esteban, C., and Izpisúa Belmonte JC. (2005) Non-canonical Wnt signaling regulates midlineconvergence of organ primordia during zebrafish development. Genes and Development 19: 164-175.

Buceta, J., Ibanes, M., Rasskin-Gutman,D., Okada, Y., Hirokawa, N., and Izpisúa Belmonte JC. (2005). Nodal CiliaDynamics and the Specification of the Left/Right Axis in Early EmbryoDevelopment. Biophysical Journal 89: 2199-2209.

Rasskin-Gutman, D. and Izpisúa Belmonte JC. (2004) Embryos at the core of life, Development 130: 5564-5566.

Raya, A., Consiglio, A., Kawakami, Y.,Rodriguez-Esteban, C., and Izpisúa Belmonte JC. (2004) The zebrafish asa model of heart regeneration. Cloning and Stem Cells 6(4): 345-351.

Kawakami, Y., Rodriguez Esteban, C.,Matsui, T., Rodriguez-Leon, J., Kato, S. and Izpisúa Belmonte JC. (2004) Sp8 and Sp9 regulate Fgf8 expression and limb outgrowth in vertebrateembryos. Development 31: 4763-4774.

Raya, A. and Izpisúa Belmonte JC. (2004) Unveiling the establishment of left-rightasymmetry in the chick embryo. Mech. Dev 121: 1043-1054.

Kang, J.S., Oohashi, T., Kawakami, Y.,Bekku, Y., Izpisúa Belmonte JC and Ninomiya, Y. (2004) Characterization ofdermacan, a novel zebrafish lectican gene, expressed in dermal bones. Mechanismsof Development 121(3): 301-312.

Huang Q, Raya A, DeJesus P, Chao SH,Quon KC, Caldwell JS, Chanda SK, Izpisúa Belmonte JC, Schultz PG. (2004) Identification of p53 regulators by genome-wide functional analysis. Proc. Natl. Acad. Sci. USA 101(10): 3456-3461.

Correa, R.,Tergaonkar, V., Ng, J., Izpisúa Belmonte JC, and Verma, I. (2004) Notochorddifferentiation by the T-box gene ntl in zebrafish is regulated by NFkb. Molecular Cell Biology 24(12): 5257-5268.

Raya, A. and Izpisúa Belmonte JC. (2004) Sequential transfer of left-rightinformation during vertebrate embryo development. Curr. Op. Genes and Development 14: 575-581.

Rasskin-Gutman, D. and Izpisúa Belmonte JC. (2004) Theoretical morphology developmentalasymmetries. BioEssays  26(4): 405-412.

Saez, E., Rosenfeld, J., Livolsi, A.,Lombardo, E., Olson, P., Nelson,M., Banayo, E., Cardiff, R.D., Izpisúa Belmonte JC and Evans, R.M. (2004) PPARg signaling exacerbates mammary gland tumor development. Genes and Development 18(5): 528-540.

Timmerman, L.A., Grego-Bessa, J.,Bertrán, E., Pérez-Pomares, J.M., Diez, J., Aranda, S., Palomo, S., Raya, A., McCormick, F., Izpisúa Belmonte JC and de la Pompa, J.L. (2004) Notchpromotes epithelial-mesenchymal transitions during heart development andtransformation. Genes and Development 18(1): 99-115.

Raya, A., Kawakami, Y., Rodriguez-Esteban,C., Ibañes, M., Rasskin-Gutman, D., Rodriguez-León, J., Büscher, D., Feijó, J.A. and Izpisúa Belmonte JC. (2004) Notch activity acts as asensor for extracellular calcium during vertebrate left-rightdetermination. Nature 427: 121-128.

Raya, A., Koth, C.M., Büscher, D.,Kawakami, Y., Itoh, T., Raya, R.M., Sternik, G., Tsai, H.-J., Rodriguez-Esteban, C. and Izpisúa Belmonte JC. (2003) Activation of Notchsignaling pathway precedes heart regeneration in zebrafish. Proc. Natl.Acad. Sci. USA, Special Supplement on Stem Cells and the Future of Regenerative Medicine 100: 11889-11895.

Groppe, J., Greenwald, J., Wiater, E.,Rodriguez-Leon, J., Economides, A.N., Kwiatkowski, W., Baban, K., Affolter, M., Vale, W.W., Izpisúa Belmonte JC and Choe, S. (2003) Structural basis ofBMP signaling inhibition by Noggin, a novel twelve-membered cystine knotprotein. The Jnl. of Bone and Joint Surgery 85-A, Suppl. 3: 52-58.

Raya, A., Kawakami, Y.,Rodriguez-Esteban, C., Büscher, D., Koth, C.M., Itoh, T., Morita, M.,Raya, R.M., Dubova, I., Grego Bessa, J., de la Pompa, J.L. and Izpisúa Belmonte JC. (2003) Notch activity induces Nodal expression andmediates the establishment of left-right asymmetry in vertebrate embryos. GenesDev. 17: 1213-1218.

Kawakami, Y., Rodriguez-Leon, J., Koth,C.M., Büscher, D., Itoh, T., Raya, A., Ng, J.K., Rodriguez Esteban, C.,Takahashi, S., Henrique, D., Schwarz, M.F., Asahara, H. and Izpisúa Belmonte JC. (2003) MKP3 mediates the cellular response to FGF8signalling in the vertebrate limb. Nature Cell Biology 5: 513-519.

Groppe, J., Greenwald, J., Wiater, E.,Rodriguez-Leon, J., Economides, A.N., Kwiatkowski, W., Affolter, M., Vale, W.W., Izpisúa Belmonte JC and Choe, S. (2002) Structural basis of BMPsignalling inhibition by the cystine knot protein Noggin. Nature 420: 636-642.

Izpisúa Belmonte JC. (2002) The limb identitygene Tbx5 promotes limb initiation by interacting with Wnt-2band Fgf-10. Development 129: 5161-5170.

Ng, J., Kawakami, Y., Büscher, D., Raya,A., Itoh, T., Koth, C., Rodríguez Esteban, C., Rodriguez Leon, J., Garrity, D.M., Fishman, M.C. Hurle, J.M. and Izpisúa Belmonte JC. (Ed.). (2002) Limb Development, Special Issue. Intl.Jnl. of Dev. Biol., Volume 46, Issue No. 7.

Diaz Trelles, R., Rodriguez Leon, J., Kawakami, Y., Simoes, S. and Izpisúa Belmonte JC. (2002) Expression of thechick vascular endothelial growth factor D gene during limbdevelopment. Mechanisms of Development 116: 239-242.

Capdevila, J. and Izpisúa Belmonte JC. (2001) Patterning mechanisms controlling vertebrate limb development. Ann. Rev. Cell Dev. Biol. 17: 87-132.

Rodriguez-Esteban, C., Raya, A.,Capdevila, J. and Izpisúa Belmonte JC. (2001) ¿Cómo distingue el cuerpo la izquierda de la derecha? Investigacion y Ciencia 300: 62-69.

Mukhopadhyay, M., Shtrom, S.,Rodriguez-Esteban, C., Chen, L., Tsukui, T., Gomer, L., Dorward, D.W.,Glinka, A., Grinberg, A., Huang, S.-P., Niehrs, C., Izpisúa Belmonte JC and Westphal, H. (2001) Dickkopf1 is required for embryonic headinduction and limb morphogenesis in the mouse. Developmental Cell 1: 423-434.

Tavares, A.T., Izpisúa Belmonte JC and Rodriguez-Leon, J. (2001) Developmental expression of chick Twistand its regulation during limb patterning. Intl. Jnl. of Dev.Biol. 45: 707-713.

Rodriguez-Esteban, C., Capdevila, J., Kawakami, Y. and Izpisúa Belmonte JC. (2001) Wnt signaling and PKAcontrol Nodal expression and left-right determination in the chickembryo. Development 128: 3189-3195.

Sharma, K. and Izpisúa Belmonte JC. (2001) Development of the limb neuromuscular system. Curr. Opin. CellBiol. 13: 204-210.

Kawakami, Y., Capdevila, J., Büscher,D., Itoh, T., Rodriguez-Esteban, C., and Izpisúa Belmonte JC. (2001) Wnt signals control FGF-dependent limb initiation and AER induction in thechick embryo. Cell 104: 891-900.

Capdevila, J. and Izpisúa Belmonte JC. (2000) Perspectives on the evolutionary origin of tetrapod limbs. Jnl.of Exp. Zool 288: 287-303.

Ruiz-Lozano, P., Ryan, A.K. and Izpisúa Belmonte JC. (2000) Left-right axis determination. Trends inCardiovascular Med 10: 258-262.

Liang, J.O., Etheridge,A., Hantsoo, L., Rubinstein, A.L., Nowak, S.J., Izpisúa Belmonte JC, and Halpern, M.E. (2000) Asymmetric Nodal signaling in the zebrafish diencephalons positionsthe pineal organ. Development 127: 5101-5112.

Ryan, A.K. and Izpisúa Belmonte JC. (2000) Establishing a left-right axis in the embryo. IUBMB Life 50: 1-11.

Tavares, A.T., Tsukui, T., and Izpisúa Belmonte JC. (2000) Evidence that members of the Cut/Cux/CDP familymay be involved in AER positioning and polarizing activity during chicklimb development. Development 127: 5133-5144.

Yokoyama, H., Yonei-Tamura, S., Endo,T., Izpisúa Belmonte JC, Tamura, K. and Ide, H. (2000) Mesenchymewith Fgf-10 expression is responsible for regenerative capacity in Xenopuslimb buds. Developmental Biol 219: 18-29.

Capdevila, J., Vogan, K.J., Tabin, C.J.and Izpisúa Belmonte JC. (2000) Mechanisms of left-right determinationin vertebrates. Cell 101: 9-21.

Capdevila, J. and Izpisúa Belmonte JC. (2000) Knowing left from right: the molecular basis of lateralitydefects. Mol. Med. Today 6: 112-118.